Search algorithm reveals nearly 200 new kinds of CRISPR systems
Microbial sequence databases contain a wealth of information about enzymes and other molecules that could be adapted for biotechnology. But these databases have grown so large in recent years that...
View ArticleMaking genetic prediction models more inclusive
While any two human genomes are about 99.9 percent identical, genetic variation in the remaining 0.1 percent plays an important role in shaping human diversity, including a person’s risk for developing...
View ArticleIt takes three to tango: transcription factors bind DNA, protein, and RNA
Transcription factors could be the Swiss Army knives of gene regulation; they are versatile proteins containing multiple specialized regions. On one end they have a region that can bind to DNA. On the...
View ArticleAtlas of human brain blood vessels highlights changes in Alzheimer’s disease
Your brain is powered by 400 miles of blood vessels that provide nutrients, clear out waste products, and form a tight protective barrier — the blood-brain barrier — that controls which molecules can...
View ArticleWith fractured genomes, Alzheimer’s neurons call for help
A new study by researchers in The Picower Institute for Learning and Memory at MIT provides evidence from both mouse models and postmortem human tissue of a direct link between two problems that emerge...
View ArticleNew CRISPR-based map ties every human gene to its function
The Human Genome Project was an ambitious initiative to sequence every piece of human DNA. The project drew together collaborators from research institutions around the world, including MIT's Whitehead...
View ArticleScientists seek insight into Parkinson’s, addiction by tracking gene...
Two MIT neuroscientists have been awarded grants from the G. Harold and Leila Y. Mathers Foundation to screen for genes that could help brain cells withstand Parkinson’s disease and to map how gene...
View ArticleFast modeling of cancer mutations
Sequencing the genomes of tumor cells has revealed thousands of genetic mutations linked with cancer. However, sifting through this deluge of information to figure out which of these mutations actually...
View ArticleKellis to lead MIT team in new phase of GTEx project to elucidate basis of...
The National Institutes of Health have awarded eight grants as part of a new phase of the Genotype-Tissue Expression (GTEx) project to study the role that genomic variation plays in modulating gene...
View ArticleIt’s in the genes — but whose?
In 2003, when the human genome had been sequenced, many people expected a welter of new therapies to follow, as biologists identified the genes associated with particular diseases.But the process that...
View ArticleBroad Institute awarded first patent for CRISPR-Cas9 system
The Broad Institute of MIT and Harvard recently announced that it has been issued a patent for a CRISPR-Cas9 system that's enabling scientists to modify genes and better understand the biology of...
View ArticleResearch reveals structure of key CRISPR complex
Researchers from MIT and the Broad Institute have teamed up with colleagues from the University of Tokyo to form the first high-definition picture of the Cas9 complex — a key part of the CRISPR-Cas...
View ArticleUnusual suspects
DNA stores the information of life, proteins provide the action, and in between sits elusive RNA, which serves both as a database of information and as a molecular machine. RNA is more flexible than...
View ArticleSpeeding up gene discovery
Since the completion of the Human Genome Project, which identified nearly 20,000 protein-coding genes, scientists have been trying to decipher the roles of those genes. A new approach developed at MIT,...
View ArticleControlling genes with light
Although human cells have an estimated 20,000 genes, only a fraction of those are turned on at any given time, depending on the cell’s needs — which can change by the minute or hour. To find out what...
View ArticleResearch update: Genome editing becomes more accurate
Earlier this year, MIT researchers developed a way to easily and efficiently edit the genomes of living cells. Now, the researchers have discovered key factors that influence the accuracy of the...
View ArticleReading DNA, backward and forward
MIT biologists have discovered a mechanism that allows cells to read their own DNA in the correct direction and prevents them from copying most of the so-called “junk DNA” that makes up long stretches...
View ArticleCardiac development needs more than protein-coding genes
When the human genome was sequenced, biologists were surprised to find that very little of the genome — less than 3 percent — corresponds to protein-coding genes. What, they wondered, was all the rest...
View ArticleEditing the genome with high precision
Researchers at MIT, the Broad Institute and Rockefeller University have developed a new technique for precisely altering the genomes of living cells by adding or deleting genes. The researchers say the...
View ArticleEvolution: It’s all in how you splice it
When genes were first discovered, the canonical view was that each gene encodes a unique protein. However, biologists later found that segments of genes can be combined in different ways, giving rise...
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